Heart failure with reduced ejection fraction (HFrEF) is a significant burden on healthcare, and unmet need remains


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Progressive HFrEF symptoms affect a patient’s functional status and HRQoL HF is common and poses a tremendous burden on healthcare systems.1,2,3,5,6

HF is a pandemic affecting > 64 million people worldwide.6,*

HF is becoming more common and more deadly, considered a global pandemic.
There is a 20–45 percent lifetime risk of developing HF for people 45–95 years old. Approximately 50 percent of patients with HF have been diagnosed with HFrEF.
HF lowers HRQoL in many areas, including physical, cognitive, psychological, social, and financial HF has a significant economic impact on society.2,10
HF mortality rates within 1 year of hospitalization can be as high as 45 percent
Mortality and hospitalization rates are high for heart failure. HFrEF poses a significant burden on healthcare systems and represents an unmet therapeutic need. Mortality and rehospitalization rates are high following HF hospitalizations.1,3,4,11

High mortality and hospitalization readmission rates persist in HF.1,3,4,11,12

For patients with HF, the risk of death increases with each additional hospitalization

HF is responsible for a high volume of hospital visits.1,3,13

For patients with HF, the risk of death increases with each additional hospitalization
The cardinal signs and symptoms of HF include dyspnea, edema, and reduced exercise capacity

Recurrent hospitalizations result in worsening of myocardial function.14

Recurrent hospitalizations are associated with worsening of myocardial function
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